GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs683250 | 1 | rs634368 | chr11:83324911 | CCDC90B | chr11:82972506-82997414:- | 0.15 | 3.68 | 0.000257 | Subcortical brain region volumes |
| THCA | cis | rs601339 | 1 | rs635400 | chr12:123171089 | EIF2B1 | chr12:124105571-124118247:- | 0.17 | 3.35 | 0.000876 | Adiponectin levels |
| THCA | cis | rs6479891 | 1 | rs63749191 | chr10:65119887 | LOC84989 | chr10:65224989-65226320:+ | 0.27 | 4.39 | 1.39E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs63749191 | chr10:65119887 | NRBF2 | chr10:64893007-64914785:+ | 0.28 | 4.77 | 2.5E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs599083 | 1 | rs638076 | chr11:68202580 | LOC645332 | chr11:67559240-67572807:- | 0.19 | 4.09 | 5.16E-5 | Bone mineral density (spine) |
| THCA | cis | rs568617 | 1 | rs641018 | chr11:65655393 | CTSW | chr11:65647284-65651212:+ | -0.6 | -15.88 | 6.69E-46 | Crohn's disease |
| THCA | cis | rs568617 | 1 | rs641018 | chr11:65655393 | SNX32 | chr11:65601410-65621170:+ | 0.63 | 9.47 | 1.33E-19 | Crohn's disease |
| THCA | cis | rs559928 | 1 | rs641168 | chr11:64146289 | GPR137 | chr11:64037534-64056965:+ | 0.16 | 3.81 | 0.000154 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs559928 | 1 | rs641168 | chr11:64146289 | VEGFB | chr11:64002266-64006258:+ | 0.14 | 3.85 | 0.000132 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs726288 | 1 | rs6413523 | chr10:81706135 | LOC219347 | chr10:81805991-81838949:- | -0.52 | -5.52 | 5.7E-8 | Rheumatoid arthritis |
| THCA | cis | rs1552244 | 1 | rs6414438 | chr3:10073824 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.24 | 2.65E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6414438 | chr3:10073824 | VHL | chr3:10183319-10193744:+ | -0.17 | -3.95 | 8.96E-5 | Alzheimer's disease |
| THCA | cis | rs6421571 | 1 | rs6421571 | chr11:118743772 | TREH | chr11:118528942-118550381:- | 0.23 | 3.75 | 0.000199 | Primary biliary cirrhosis |
| THCA | cis | rs1411478 | 1 | rs6425657 | chr1:180956905 | MR1 | chr1:181003139-181024633:+ | -0.13 | -3.59 | 0.000363 | Progressive supranuclear palsy |
| THCA | cis | rs1411478 | 1 | rs6425657 | chr1:180956905 | STX6 | chr1:180913175-180992046:- | -0.2 | -4.13 | 4.32E-5 | Progressive supranuclear palsy |